Impact of future HERA data on the determination of proton parton distribution functions using the ZEUS QCD fit

The high precision and large kinematic coverage of the data from the HERA-I running period (1994-2000) have already allowed precise extractions of proton parton distribution functions (PDFs). The HERA-II running program is now underway and is expected to provide a substantial increase in the luminosity collected at HERA. In this paper, a study is presented which investigates the potential impact of future data from HERA on the proton PDF uncertainties, within the currently planned running scenario. In addition, the effect of a possible future measurement of the longitudinal structure function, FL, on the gluon distribution is investigated.Comment: 5 pages, 2 figures, in proceedings of the XIII International Workshop on Deep Inelastic Scattering - DIS 2005, Madison, Wisconsin, 200

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit. To examine the effect of such therapy on transmission, Gambian children with Plasmodium falciparum malaria were treated with standard regimens of chloroquine or pyrimethamine-sulfadoxine alone or in combination with 1 or 3 doses of artesunate. The infectivity to mosquitoes of gametocytes in peripheral blood was determined 4 or 7 days after treatment. Infection of mosquitoes was observed in all treatment groups and was positively associated with gametocyte density. The probability of transmission was lowest in those who received pyrimethamine-sulfadoxine and 3 doses of artesunate, and it was 8-fold higher in the group that received pyrimethamine-sulfadoxine alone. Artesunate reduced posttreatment infectivity dramatically but did not abolish it completely. The study raises questions about any policy to use pyrimethamine-sulfadoxine alone as the first-line treatment for malaria

Impact of the International Rugby Board’s experimental law variations on the incidence and nature of match injuries in southern hemisphere professional rugby union

Objective. To examine the epidemiology of match injuries in southern hemisphere professional rugby union and assess the impact of the International Rugby Board (IRB) Experimental Law Variations.Setting. One-season whole population prospective cohort.Subjects. Twenty-seven teams (813 players) taking part in the2008 Super 14 and Vodacom Cup competitions. Outcome measures. Incidence, severity, location, type and cause of injury.Results. The incidence in the Super 14 competition (96.3 injuries/1 000 player-match hours; 95% confidence interval (CI) 69.0 - 111.7) was significantly higher (p=0.003) than that in the Vodacom Cup (71.2; CI 60.0 - 84.5); injury severity was significantly lower (

Non-parametric analysis of the rest-frame UV sizes and morphological disturbance amongst L* galaxies at 4<z<8

We present the results of a study investigating the sizes and morphologies of redshift 4 < z < 8 galaxies in the CANDELS GOODS-S, HUDF and HUDF parallel fields. Based on non-parametric measurements and incorporating a careful treatment of measurement biases, we quantify the typical size of galaxies at each redshift as the peak of the log-normal size distribution, rather than the arithmetic mean size. Parameterizing the evolution of galaxy half-light radius as $r_{50} \propto (1+z)^n$, we find $n = -0.20 \pm 0.26$ at bright UV-luminosities ($0.3L_{*(z=3)} < L < L_*$) and $n = -0.47 \pm 0.62$ at faint luminosities ($0.12L_* < L < 0.3L_*$). Furthermore, simulations based on artificially redshifting our z~4 galaxy sample show that we cannot reject the null hypothesis of no size evolution. We show that this result is caused by a combination of the size-dependent completeness of high-redshift galaxy samples and the underestimation of the sizes of the largest galaxies at a given epoch. To explore the evolution of galaxy morphology we first compare asymmetry measurements to those from a large sample of simulated single S\'ersic profiles, in order to robustly categorise galaxies as either `smooth' or `disturbed'. Comparing the disturbed fraction amongst bright ($M_{UV} \leq -20$) galaxies at each redshift to that obtained by artificially redshifting our z~4 galaxy sample, while carefully matching the size and UV-luminosity distributions, we find no clear evidence for evolution in galaxy morphology over the redshift interval 4 < z < 8. Therefore, based on our results, a bright ($M_{UV} \leq -20$) galaxy at z~6 is no more likely to be measured as `disturbed' than a comparable galaxy at z~4, given the current observational constraints.Comment: 29 pages, 25 figures, 4 tables, published in MNRA

A rapid review examining purchasing changes resulting from fiscal measures targeted at high sugar food and non-alcoholic drinks

To aim of the review was to examine the most recent (2010 onwards) research evidence on the health and behavioural impacts, in adults and children, of fiscal strategies that target high sugar foods and sugar-sweetened drinks (SSDs). A pragmatic rapid review was undertaken using a systematic search strategy. The review was part of a programme of work to support policy development in relation to high sugar food and SSDs. A total of 11 primary research publications were included, describing evidence from France (n = 1), the Netherlands (n = 3), and the United States of America (n = 7), assessed through a variety of study designs, with the majority in adult populations (n = 10). The evidence reviewed focused on consumer behaviour outcomes and suggested that fiscal strategies can influence purchases of high sugar products. Although the majority of studies (n = 10), including three field studies, demonstrated that an increase in the price of high sugar foods and SSDs resulted in a decrease in purchases, eight studies were conducted in a laboratory or virtual setting which may not reflect real-life situations. Findings from this review support evidence from the broader literature that suggests that fiscal measures can be effective in influencing the purchasing of high sugar foods and SSDs

Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV Core DII protein

Host cell lipid droplets (LD) are essential in the hepatitis C virus (HCV) life cycle and are targeted by the viral capsid core protein. Core-coated LDs accumulate in the perinuclear region and facilitate viral particle assembly, but it is unclear how mobility of these LDs is directed by core. Herein we used two-photon fluorescence, differential interference contrast imaging, and coherent anti-Stokes Raman scattering microscopies, to reveal novel core-mediated changes to LD dynamics. Expression of core protein’s lipid binding domain II (DII-core) induced slower LD speeds, but did not affect directionality of movement on microtubules. Modulating the LD binding strength of DII-core further impacted LD mobility, revealing the temporal effects of LD-bound DII-core. These results for DII-core coated LDs support a model for core-mediated LD localization that involves core slowing down the rate of movement of LDs until localization at the perinuclear region is accomplished where LD movement ceases. The guided localization of LDs by HCV core protein not only is essential to the viral life cycle but also poses an interesting target for the development of antiviral strategies against HCV